Cells with mutation and expressed with p53 or Tp53 are potentially more likely to result in cancer.
The p53 or TP53 gene is the one that is most frequently altered in cancer patients. Over 50% of tumors have a defective or absent p53 gene. Most mutations in the p53 gene are acquired.
Although germline p53 mutations are uncommon, those who have them have an increased chance of developing a wide range of cancers.
The majority of cancer cells, known as carcinomas, originate from tissues that line the inner or outer surfaces of the body and are called epithelial in origin. Leukemia typically develops in the bone marrow, which is responsible for creating new blood cells. Myeloma and lymphoma are immune system-related cancers.
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