Modifications you would make in cancer cells that are over expressing oncogenes are Increase histone methylation while decreasing histone acetylation and phosphorylation.
It is generally known that both histone deacetylation and DNA methylation suppress gene transcription. In contrast, when histones are deacetylated by HDAC, their electrostatic contacts with DNA become stronger, resulting in relaxed chromatin that upregulates transcription. A more open conformation of chromatin is produced as a result of histone phosphorylation, which gives the histone a negative charge. As a result, it is linked to gene expression and is engaged in chromatin remodeling and DNA damage repair.
Methyltransferases and demethylases, respectively, catalyze the site-specific methylation and demethylation of histone residues. In general, transcriptional silencing marks encourage the establishment of heterochromatin while transcriptional activation markers improve the permissibility of gene transcription.
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