Somatic hypermutation occurs only in the heterologous antigen. regions of rearranged heavy and light chains.
Somatic hypermutation is a cellular mechanism by which the immune system adapts to new foreign elements faced by it, as seen in class-switching elements when changing classes.
Somatic hypermutation is a process by which point mutations in both the heavy and light chain V regions of antibodies accumulate at a rate approximately 106-fold higher than the background mutation rate observed in other genes.
Affinity maturation is the process by which antibodies increase affinity, avidity, and antipathogen activity, and is the result of somatic hypermutation of immunoglobulin genes in B cells, coupled with antigen-binding selection.
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