Describe how the defect in the Single-Mutant (Sev R7 precursor cell causes the cell to become cone cell instead of a photoreceptor cell. No response entered (c) The scientists predict that the presence of activated Ras in the Double-Mutant (Sev RasD) R7 precursor cell will enable the cell to differentiate into an R7 photoreceptor cell Based on Figure evaluate the likely accuracy of their prediction_ No response entered (d) The Sev RTK is expressed In more cell types than just R7 precursor cells, and It appears to be important in determining the phenotypes of these Other cells. Explain how one receptor can Induce different phenotypes In different cell types: No response entered

Respuesta :

The Ras protein cannot bind to Sev RTK, so there is no signaling pathway causing the cell to become a cone cell.

RAS proteins play an important role in normal development. Active RAS promotes cell growth, proliferation, and migration. RAS in normal cells receives and obeys signals to rapidly switch between active (GTP form) and inactive (GDP form) states.

Ras proteins are proto-oncogenes that are frequently mutated in cancers in humans. They are encoded by three genes that are widely expressed: HRAS, KRAS, and NRAS. These proteins are GTPases, which act as molecular switches, regulating pathways involved in cell proliferation and survival. KRAS is the most frequently mutated of the three Ras isoforms, accounting for 75% of Ras-mutant cancers in 19 of the 29 cancer types listed in Table 1.

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