When action potential reaches the end of the axon , it causes neurotransmitter containing vesicles to blend with the membrane, that release neurotransmitter molecules inside synaptic cleft .
In general, electrical impulse from the action potential reaches the end of the axon, this signals terminal buttons also release neurotransmitters into the synapse. A neurotransmitter also have chemical that relays signals across the synapses between neurons.
Hence, the action potential when reaches the axon terminal, the depolarization helps voltage dependent calcium channel to open. The process of neurotransmitter release is called exocytosis.
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