The modifications in cancer cells that are over expressing oncogenes will be of decreasing acetylation of histones and increase phosphorylation of histones.
An oncogene is a gene that has the potential to cause cancer. In tumour cells, these genes are typically mutated, or expressed at high levels. Most traditional cells can endure a programmed kind of speedy death once vital functions are altered and haywire.
Each histone molecule incorporates a long tail wealthy in essential amino acid residues (K), that are acylation modification sites. factor activation and repression square measure regulated by acylation of core simple protein, and simple protein acylation is mediate by coactivators (histone acetyltransferase: HATs) and corepressors (histone deacetylases: HDACs).
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