There are more negatively charged particles inside the membrane than outside, according to the resting membrane potential's negative value.
Transmembrane channels called voltage-gated potassium channels (VGKC) are in charge of repolarizing the depolarized cell to its resting state following each nerve impulse. As a result, they play a crucial role in controlling neuronal excitability in the central nervous system and peripheral nervous system.
Based on both their ion-conducting capabilities and their interactions with other proteins in signaling complexes at the plasma membrane, voltage-gated potassium channels control the passage through cell cycle checkpoints. Throughout the cell cycle, the membrane potential fluctuates.
Potassium rushes out of the cell along its electrochemical gradient when a set of voltage-gated potassium channels open. The membrane potential is swiftly reduced by these occurrences, returning it to its regular resting condition.
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