Answer: A client who is on long-term glucocorticoid therapy is at risk of developing Osteoporosis.
Explanation:
What are Glucocorticoids?
Glucocorticoids are steroid hormones generated by the adrenal cortex (gluco-corti-coids: glucose-cortex-steroids). Glucocorticoids play an important part in the body's glucose, protein, and fat metabolism. Stress raises circulating glucocorticoid levels, which act directly on the hypothalamus to decrease GnRH synthesis.
Glucocorticoids cause one of the well-known and serious side effects of long-term glucocorticoid therapy osteoporosis. Up to 40% of people taking long-term glucocorticoids experience bone loss, which leads to fractures. Glucocorticoids have both direct and indirect effects on bone tissue, resulting in bone loss. These medications have a direct detrimental effect on bone cells, resulting in a slower rate of bone formation. They can also interfere with the body's calcium processing and impact sex hormone levels.
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