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The experiment which best supports the idea that a transcriptional regulatory sequence can be located in an intron of a gene is: The intron of a gene is deleted, the gene is introduced into mouse cells, and the mRNA levels are measured. These mRNA levels are compared to a normal gene which is also introduced into mouse cells. The mutated gene shows no mRNA transcription, whereas the normal one does.
What is an intron of a gene?
An intron is a region which resides within a gene but does not remain in the final mature mRNA molecule following transcription of the gene and does not code for amino acids which make up the protein encoded by the gene. Most protein-coding genes in the human genome consist of exons and introns.
Introns are crucial because the protein repertoire or variety is greatly enhanced by alternative splicing in which introns take partly important roles. Alternative splicing is a controlled molecular mechanism producing multiple variant proteins from a single gene in a eukaryotic cell.
Although part of your question is missing, you might be referring to this full question: Which of the following experiments best supports the idea that a transcriptional regulatory sequence can be located in an intron of a gene?
- The intron of a gene is deleted, the gene is introduced into mouse cells, and the mRNA levels are measured. These mRNA levels are compared to a normal gene which is also introduced into mouse cells. The mutated gene shows no mRNA transcription, whereas the normal one does.
- The deleted intron that acts as a transcriptional regulatory element would result in a lack of mRNA, whereas the mouse cells with the normal gene would show mRNA transcription, thus serving as a positive control.
Learn more about introns at: https://brainly.com/question/14317818
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