The drug molecules bonded to the viral reverse transcriptase enzyme, thus preventing the virus from making a DNA copy of its RNA genome.
Drugs called reverse transcriptase inhibitors are used to treat and control HIV. The medicine belongs to the class of antiretrovirals. This exercise examines the benefits, side effects, and indications for RTIs as an effective HIV management tool (and other disorders when applicable). This activity will highlight the mechanism of action, adverse event profile, and other critical elements important for members of the interprofessional healthcare team in the management of patients with HIV and related conditions, such as off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, and relevant interactions.There are two subclasses of medications under the category of reverse transcriptase inhibitors. The first class of reverse transcriptase inhibitors are nucleoside/nucleotide inhibitors, and the second class is non-nucleoside inhibitors.
The FDA initially approved the nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) as the first class of antiretroviral medications. NRTIs are administered as prodrugs and must enter the host cell where they must be phosphorylated in order to function. Cellular kinases inside the host cell will then cause the medication to become active.
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