micrornas regulate gene expression by bringing the risc complex to a mrna with perfectly complementary sequence, which allows the risc complex to cut the mrna into two pieces

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10-12-2022
Biology

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micrornas regulate gene expression by bringing the risc complex to a mrna with perfectly complementary sequence, which allows the risc complex to cut the mrna into two pieces

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kjuli1766 kjuli1766 · Answer 1 · 2022-12-15T18:13:02+01:00

The expression of miRNAs is driven by multiple factors and molecular mechanisms, ranging from those affecting DNA copy number, CpG methylation, transcription factors and miRNA biogenesis to those affecting the availability of miRNA binding sites on mRNAs.

MicroRNAs regulate gene expression primarily by binding to messenger RNA (mRNA) in the cytoplasm of cells. Instead of being rapidly translated into protein, the tagged mRNA is either destroyed and its components recycled or stored and transferred.

The degree of complementarity between guides and mRNA targets determines which silencing mechanism is used. After cleavage of the target messenger RNA (mRNA) and subsequent degradation or inhibition of translation Figure.

Learn more about MicroRNAs regulate here

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