prodrugs are an area of medicinal chemistry that has been extensively researched over the last several years. prodrugs are designed to be initially inactive until further activated into the active form of the drug (which could include also esterification or trans-esterification event). for example: aspirin is a prodrug that gets converted to salicylic acid. (a) draw a complete arrow-pushing mechanism showing how aspirin is converted into salicylic acid (say by the stomach acylating enzyme at low ph). a scheme of the overall transformati

A prodrug is a chemical that is transformed before it has pharmacological effects. Or in other words, after you take a prodrug, it basically changes in your body before it starts working.

There are two major types of prodrugs. These categories are based on how prodrugs are generally converted in the body:

1) Type I prodrugs turn into their active forms inside of cells.

2) Type II prodrugs turn into their active forms outside of cells, such as in blood or other fluids.

Before a prodrug can provide its intended effects in your body, it firsts needs to be broken down. A prodrug’s type affects how the medication is transformed or activated that is whether it occurs inside or outside your cells.

Different types of prodrugs can also impact the drug interactions. Certain interactions may prevent a prodrug from becoming active.

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