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Some of the problems included that the ban on alcohol increased the value of alcohol, attracting mobs and other criminals to start producing, smuggling and selling it. Another would be the fact that people started making moonshine, and poisoning themselves with it, because they didn't know how to properly make the substance. 
Alcohol Prohibition Was a Failure. National prohibition of alcohol (1920-33)—the “noble experiment”—was undertaken to reduce crime and corruption, solve social problems, reduce the tax burden created by prisons and poorhouses, and improve health and hygiene in America

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Prohibition led to the rapid rise of speakeasies (sometimes called blind pigs or bling tigers). Speakeasies owned by gangsters replaced neighborhood bars. They promoted heavy drinking, gambling and prostitution. ... That was double the number of saloons and illegal joints in the pre-Prohibition era.