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Macronutrients are a substance required in relatively large amounts by living organisms, in particular.
a type of food (e.g., fat, protein, carbohydrate) required in large amounts in the human diet.
a chemical element (e.g., potassium, magnesium, calcium) required in large amounts for plant growth and development.

a chemical element or substance required in trace amounts for the normal growth and development of living organisms.