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metchelle
In fractional crystallization, what makes this disadvantageous is that multiple runs are needed in the process. This is to purify the mixture adequately but this still does not reach that 100% purity. In addition to the disadvantage of this, some of the mixture is lost during the process. This is because of so many steps being done. Hope this helps.
sarajevo

Low yield as a lot of the substance that is being purified is lost due to the several steps involved. Fractional crystallization is a cascade process as it involves the purification of the substance to the highest degree of purity. Also fractional crystallization is ineffective in separating enantiomorphs which have identical physical property.

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