What is not true for delayed type hypersensitive reactions (DTH)?
1) The IL-2, γ-IFN and IL-12 play an important role
2) Macrophage activation and cytokine production
3) They are directed against intracellular viruses and bacteria
4) They are mediated by Treg-derived cytokines
5) E) They develop 24-48 hours after the antigenic challenge