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Flexibility, or range of motion around the joints, also ranks as an important component of health-related fitness. Lack of flexibility in the lower back and posterior thigh is thought to contribute to low back pain. Extreme lack of flexibility also has a deleterious effect on the quality of life by limiting performance. "exercise." Britannica School. Encyclopaedia Britannica, Inc., 2013. Web. 21 Oct. 2013. How is the word deleterious used in this excerpt?