A 33 year-old female with a past medical history significant for gastroesophageal reflux disease (GERD) and hypertension presents to the emergency department with a hard "pimple" on her right leg that is erythematous and painful
(currently erythematous area is about 200 cm2). This has worsened since she first noticed it several days ago which brought her into her physician. She reports a rash to sulfa medications in the past. Her current medications are lisinopril 20mg daily, fluticasone 1 spray each nostril daily, and Ortho Tri-cyclen 1 pill daily. Her vitals are the following: BP 100/60, Heart rate 110, Temperature 102.3 F, Respiratory rate 14. Local MRSA rates are 65%. The decision is made to admit the patient to the medicine ward for management.
Which of the following intravenous agents in addition to incision/drainage of the abscess would be appropriate to treat her acute bacterial skin/skin structure infection
(ABSSSI)? Select all that apply.
A. Amoxicillin/Clavulanate
B. Ceftriaxone
C. Vancomycin
D. Daptomycin
E. Trimethoprim/Sulfamethoxazole