jeremy's SUBSTANCIA NIGRA is producing less DOPAMINE than what it needs to.
Substancia nigra is a "black substance" located in the midbrain. When there is the death of dopaminergic neurons in the substantia nigra, the quantity of dopamine decreases, causing Parkinson symptoms. With time passing, the fewer neurons Jeramy will have and those symptoms will become more severe, that is the reason why is smoking more. The nicotine from cigarettes help modulate dopamine transmission and so, to reduce some symptoms.