Pepsin, a common enzyme found in the stomach, is most active at pH values between 0.5 and 2.5. It works slowly between pH values of 2.6 and 3.4. Beyond a pH of about 3.5, it becomes completely inactive. Why does this happen?
Ph value between 0.5 and 2.5 is the optimum temperature of the pepsin which means its the most active. When temperature increase above the optimum temperature it will cause a rapid decrease in the rate of reaction. High temperature breaks the bond that keeps the enzyme (pepsin) in shape. The enzyme will denature and become inactive.
