1. the surface area to the volume ratio gets smaller as the cell gets larger. Thus, if the cell grows beyond a certain limit, not enough material will be able to cross the membrane fast enough to accommodate the increased cellular volume.
2. It depends on the unit of the ratio 6:1. If it is in cm1, then it means that it is similar to a cell of size 1 cm^3, which is normally too big to get materials from the surface.
3. a smaller cell has a better surface area to volume ratio, which means it is more efficient.