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foxmiarose
The final statement of the novel "Of Mice and Men" is "Now what the hell do you suppose is eatin' them two guys" said by Curly and Carlson after George kills Lennie. This shows that Carlson has no insight whatsoever because he doesn't understand the extremity of the situation. This statement is so significant alongside Carlson's obliviousness because it shows that what is "eatin'" at George will be the guilt that comes from not only letting Lennie inflict pain on someone else but killing his best friend. This reaffirms that the pain and guilt that 'eats' away at George will be lifelong and internal, as the surrounding men will never understand his regret, guilt, and shame.
jayilych4real

The best explanation of the significance of the final statement in this novel Of Mice And Men is:

  • It shows that Carlson does not fully understand the extent of what is happening to George

According to the given question, we are asked to make the best explanation of the significance of the final statement in this novel Of Mice And Men.

As a result of this, we can see that the final statement of the novel Of Mice and Men is about the guilt which is "eating up" George and how Carlson does not have any idea about this when George kills Lennie. This shows that George may never forgive himself for killing his best friend.

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https://brainly.com/question/20072610