Answer: Drug C has the greatest margin of safety
Explanation:
Lethal dose,[tex]LD_{50}[/tex]: An amount of drug which is sufficient to kill 50% of the population of animals in a fixed period of a time.
Effective dose,[tex]ED_{50}[/tex]: An amount of a drug which produces therapeutic response on the 50% of the population of animals ingested with that drug.
Margin of safety : It is the therapeutic index value which tells us about how safely we can use the drug for therapeutic purpose with minimal adverse effect at the same time .
Higher the value T.I safer will be the drug to use.
Lower the value T.I less safer will be the drug to use.
[tex]T.I.=\frac{LD_{50}}{ED_{50}}[/tex]
[tex]T.I._A=3.33,T.I._B=12,T.I._C=120[/tex]
Drug C has the greatest margin of safety
