Respuesta :
This is because basal-like breast cancers, do not express estrogen receptor (ER) or progesterone receptor (PR) and lacks human epidermal growth factor receptor 2 (HER2) overexpression or amplification. Due to the absence of molecular targets, they are unlikely to respond to medications such as tamoxifen and Herceptin that target the aforementioned receptors.
Due to the absence of HER2 (human epidermal growth factor receptor 2) protein, the tamoxifen and Herceptin do not work against the basal-like breast cancer.
Further Explanation:
The breast cancer occurs in the cells of the breast. They begin to divide abnormally. The cells start dividing unconditionally as compared to normal cells. They form lump or mass of cells that can metastasize to the lymph node and other regions of the body.
The unconditional division of the cells begins with the cell of the milk-producing duct. It can also begin from glandular tissue (lobules). This cancer is also associated with mutated gene inherited from either of the parent. Human epidermal growth factor receptor 2 (HER2) genes have a crucial role in breast cancer development. It is present on the surface of the cancer cells that helps in receiving signals for growth and metastasizes. Basal-like breast cancer lacks this protein due to which it cannot be treated with tamoxifen and Herceptin. The tamoxifen and Herceptin are the medicines used for cancer therapy or targeted therapy. HER2 positive cancers are really hard to treat.
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Answer Details:
Grade: High School
Subjects: Biology
Topic: Cancer
Keywords:
Breast, cancer, cell, abnormally, lump, mass, metastasize, epidermal, growth, mutated, inherited, basal, herceptin, tamoxifen, growth.
