The answer is letter A.
Humoral immunity is a situation in which antigen binds to antibodies. It is also called as the anitbody-mediated beta cellularis immune system that is found in the extracellular fluids (e.g. antibodies, complement proteins, antimicrobial peptides. Humoral immunity is mediated by macromolecules and is so named because it can be found in the humours or body fluids.