Answer:
Generally, for excitatory post synaptic potential to be generated, positively charged ions e.g. Ca+ must diffuse through the ligand gated ion channels into the pre-synaptic neuron neuron ; while preventing the outflow of positively charged ions e.g K+ from the pre- synaptic membrane.
The influx of calcium ion causes migration in the pre- synaptic neuron of vesicles contain cholinergic excitatory neurotransmitters Acetycholine. This binds to the post -synaptic receptors for opening of ligand gated ion channels for Sodium ions . The influx of Sodium ions causes depolarization which if magnitude is up to threshold levels causes EPSPs.
Therefore, to increase the magnitude of excitatory postsynaptic potentials (EPSPs) generated at a synapse;
Increasing the influx of positively charged Ca+ in the pre-synaptic neuron,while decreasing the ouflux of positively charged k+ ions; will increase number of acetycholine containing excitatory neurotransmitters vesicles migration to the pre-synaptic membrane, and therefore more acetycholine molecules diffusion into the synaptic membrane for binding with the post-synaptic receptors. This leads to opening of more sodium ion channels, for more depolarization and therefore increase in generation of EPSPs magnitude.
Explanation:
The magnitude of excitatory postsynaptic potentials (EPSPs) generated at a synapse can be increased by spatial summation.
In conclusion, the magnitude of excitatory postsynaptic potentials (EPSPs) generated at a synapse can be increased by spatial summation.
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