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The following events occur during a T-dependent humoral immune response. Put them in the correct order.
1. CD_4 cell along with T cell receptor recognizes the antigen on the APC and forms a complex.
2. Plasma cells are formed and start secreting antibodies.
3. B cell digests the antigen and displays it complexed with MHC-II marker.
4. CD_4 cell differentiates into a T helper cell (Th2).
5. B cell phagocytoses an antigen.
6. Th2 secretes cytokines to activate the B cells and undergo clonal expansion.

Respuesta :

Jamesanny20

Answer:

5, 3, 4, 1, 6, 2

Explanation:

When B cells encounter an antigen, they bind to it and internalise it through the process of phagocytosis. The antigen is then degraded and digested and presented on the surface of the b cell with MHC II molecules. Activated b cells are called Antigen presenting cells.

Activated B cells circulate through the lymph nodes and interact with helper CD4 T cells of the Th2 subtype. The CD4 T cells recognise the antigen on the MHC II and secrete cytokines on the B cells to induce proliferation and expansion of the B cells.

The B cells differentiate into plasma cells and plasma cells begin the secretion of antibodies of the IgM isotype.

luisvaschetto

The correct order is APCs phagocyte an antigen (5) and digest them (3), CD4 cells recognize the antigen (1), CD4 cells differentiate into Th2 cells (4), B cells undergo clonal expansion (6) and plasma cells secrete antibodies (2).

  • Antigen-presenting cells or APCs (e.g., dendritic cells) phagocyte antigenic particles and then display them bound by major histocompatibility complex (MHC) proteins localized on their surface.

  • CD4 cells are T cells that recognize specific antigens presented by APCs.

  • T-helper 2 (Th2) cells are cells that stimulate and also recruit specialized immune cells (e.g., basophils).

  • Clonal expansion refers to the process by which a B cell generates many copies (clones) of such cell, which have a high affinity for a given antigen.

  • Some of these clonal cells differentiate into plasma cells that secrete antibodies against a specific antigen.

In conclusion, the correct order is APCs phagocyte an antigen (5) and digest them (3), CD4 cells recognize the antigen (1), CD4 cells differentiate into Th2 cells (4), B cells undergo clonal expansion (6) and plasma cells secrete antibodies (2).

Learn more in:

https://brainly.com/question/13844257

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