Which reaction of glycolysis is bypassed in gluconeogenesis by using two enzymes?.

Pyruvate carboxylase and phosphoenolpyruvate carboxykinase (PEPCK) are two different enzymes that work together to catalyze a two-step process that bypasses the glycolytic stage mediated by pyruvate kinase.

The common metabolite of these enzymes is oxaloacetate.

The steps to convert pyruvate to phosphoenolpyruvate are as follows:

In the mitochondrion, pyruvate is converted to oxaloacetate by pyruvate carboxylase.
In the cytosol, malate or aspartate is formed from oxaloacetate and is then converted back to oxaloacetate.
Oxaloacetate is changed into phosphoenolpyruvate by the enzyme phosphoenolpyruvate carboxykinase.
Phosphoenolpyruvate reverses the processes of glycolysis to produce fructose 1,6-bisphosphate.

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