Bones will usually heal after they have been severely damaged so long as the cellular components of the endosteum and periosteum survive and there is an ossification center.
An ossification center is the starting site for cartilage ossification. The cartilage cells at this stage grow and arrange themselves in rows, which is the first stage of ossification. The first region of a bone to begin ossifying is called the main ossification center. In the middle of each growing bone during fetal development, it typically manifests. While the major centers of irregular bones typically occur in the body of the bone, they typically occur in the diaphysis/shaft of long bones.
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