Occasional doses of clemastine are acceptable during breastfeeding but large doses or prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply.
The safety of Celestamine during breastfeeding is not established. Celestamine contains a cortico-steroid, which can have a negative effect on baby's hormonal development. The presence of anti-histamine in Celestamine can cause sleepiness in your baby.
In neonates, fat content is low due to a large amount of total water in body. Due to this, the drug enters the brain due to the neonate's immature blood-brain barrier of neonate.
Neonates have immature kidneys and hence, the glomerular filtration rate is decreased. Protein binding is decreased in neonates because of the immature liver and less protein production.
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