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Long-term methamphetamine abuse has many negative consequences, including addiction. Addiction is a chronic, relapsing disease, characterized by compulsive drug seeking and use and accompanied by functional and molecular changes in the brain. hope this helps
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Taking even small amounts of methamphetamine can result in many of the same health effects as those of other stimulants, such as cocaine or amphetamines. These include:

increased wakefulness and physical activitydecreased appetitefaster breathingrapid and/or irregular heartbeatincreased blood pressure and body temperature 

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