In the pentose phosphate shunt, glucose 6-phosphate is oxidized to 6-phosphogluconate, which is then decarboxylated to ribulose 5-phosphate. What is the main metabolic role of this pathway?

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07-02-2020
Biology

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In the pentose phosphate shunt, glucose 6-phosphate is oxidized to 6-phosphogluconate, which is then decarboxylated to ribulose 5-phosphate. What is the main metabolic role of this pathway?

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annyksl annyksl · Answer 1 · 2021-11-01T20:03:15+01:00

The main metabolic role of this pathway is the production of NADPH.

We can arrive at this answer because:

All metabolic pathways have very important biological roles within an organism.

These pathways are formed by a series of reactions that transform a molecule into another essential molecule for the body, usually an energetic molecule or a carbonic compound.

In the case of the pentose phosphate pathway, the main role is to supply NADPH molecules to the body, which is a very energetic molecule that serves as a hydrogen donor coenzyme in other metabolic pathways.

In addition, pentose phosphate shunt is a blood glucose regulatory pathway that is essential for the proper functioning of the body.

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zainsubhani zainsubhani · Answer 2 · 2021-11-09T17:00:18+01:00

Answer:

1) Pentose phosphate shunt mainly provides NADPH to the body.

2) It also produces ribose 5-phosphate, which is needed for nucleotide biosynthesis.

Explanation:

1) Pentose phosphate shunt provides NADPH to the body which has the following important uses in the body:

NADPH is required for the reductive biosynthesis of fatty acids, cholesterol, and steroid hormones.
NADPH is also required for Nitric oxide (NO) synthesis. NO causes vasodilation and also acts as a neurotransmitter.
NADPH is also required in the cytochrome P450 monooxygenase system which is involved in drug metabolism in the body.

Pentose phosphate shunt is the only way through which red blood cells (RBCs) get their NADPH. This NADPH protects RBCs from reactive oxygen species.

2) This pathway also provides ribose 5-phosphate, which is produced during this pathway. This ribose 5-phosphate then goes to the pathways involved in nucleotide biosynthesis.