The normal rat will develop goiter after injection with propylthiouracil.
The medicine propylthiouracil (PTU) prevents the attachment of iodine to tyrosine residues in the thyroid gland's follicular cells, hence inhibiting the generation of thyroxine (iodinated tyrosines are linked together to form thyroxine).
While injecting propylthiouracil into a rat, it will experience hypothyroidism and goiter.
Propylthiouracil is used to treat hyperthyroidism, a condition where the thyroid gland generates excessive thyroid hormone, as well as Graves' disease.
Patients who have previously received treatment with other medications (such as methimazole) that did not perform well may also use it prior to having their thyroid surgically removed or receiving radioactive iodine therapy.
To learn more about propylthiouracil (PTU), refer
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